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KMID : 1155220110360010063
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Journal of the Korean Society of Health Information and Health Statistics
2011 Volume.36 No. 1 p.63 ~ p.75
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Dose-Response Assessment of Isoprene for Occupational Health Protection Target Level
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Kim Hyun-Ji
Shin Dong-Chun
Lim Young-Wook
Yang Ji-Yeon
Lee Yong-Jin
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Abstract
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Objectives: We investigated the method of application of dose-response assessment of domestic industry to present occupational health protection target level.
Methods: Melnick’s study data and NTP (National Toxicology Program) data using data, deterministic methods and probabilistic approaches were compared.
Results: As a result of the dose-response assessment based on Melnick’s data and NTP data, RfC (Reference Concentration) was calculated as 1.3 ppm (determined by the NTP data). So in this paper they were determined at the health protection target level of 1.3 ppm. Final results according to the type of data, the dose-response assessment method are determined.
Conclusion: Dose-response assessment based on Isoprene revealed that most important thing is toxicity endpoint to suggest health protection target level by utilizing dose-response assessment to the domestic workplace.
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KEYWORD
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Isoprene, Occupational health protection target Level, Dose-response assessment
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